home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9406b.zip
/
M9460281.TXT
< prev
next >
Wrap
Text File
|
1994-06-12
|
3KB
|
43 lines
Document 0281
DOCN M9460281
TI Neurological abnormalities associated with feline immunodeficiency virus
infection.
DT 9408
AU Phillips TR; Prospero-Garcia O; Puaoi DL; Lerner DL; Fox HS; Olmsted RA;
Bloom FE; Henriksen SJ; Elder JH; Department of Neuropharmacology,
Scripps Research Institute, La; Jolla, California 92037.
SO J Gen Virol. 1994 May;75 ( Pt 5):979-87. Unique Identifier : AIDSLINE
MED/94231177
AB Specific pathogen-free cats were infected with the Maryland strain of
FIV (FIV-MD) for the purpose of assessing the effects of FIV infection
on the central nervous system (CNS). Two separate studies were
performed, involving a total of 13 infected cats and six age-matched,
sham-inoculated controls. All animals infected with FIV-MD seroconverted
by 8 weeks post-infection and virus was recovered from peripheral blood
mononuclear cells of all infected cats. All of the infected animals had
lower absolute CD4+ cells counts and decreased CD4+/CD8+ ratios. Virus
was recovered from the cerebrospinal fluid (CSF) of certain infected
individuals, and antiviral antibody and pleocytosis were evident in the
CSF of the majority of infected cats. Additionally, virus was recovered
from tissue explants from the cerebellum, midbrain and brainstem of one
sacrificed FIV+ cat. Specific neurological changes included anisocoria,
delayed righting reflex and delayed pupillary reflex, as well as delayed
visual and auditory evoked potentials, and marked alterations in sleep
patterns similar to those reported for human immunodeficiency virus
(HIV)-positive individuals. Histological evaluation revealed the
presence of perivascular cuffing and glial nodules in FIV-infected cats.
These results indicate that FIV causes an acute neurological disease
that closely resembles the early neurological effects of HIV infection
in humans and should serve well as an animal model for
lentivirus-induced CNS disease.
DE Acute Disease Animal Brain Diseases/*PHYSIOPATHOLOGY Cats
Equilibrium Evoked Potentials, Auditory Evoked Potentials, Visual
Eye/PATHOLOGY Hippocampus/PATHOLOGY *Immunodeficiency Virus, Feline
Lentivirus Infections/*PHYSIOPATHOLOGY Reflex, Pupillary Sleep
Specific Pathogen-Free Organisms Support, U.S. Gov't, P.H.S. JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).